|Primary Care Information|
How To Medically Treat Nail Fungus
Warning: This article is for information only and can not be used to supplement your doctor's advice. You should contact your doctor for nail fungus treatment.
Treatment Of Toe Nail Fungus
Several years ago the medical management of OM was limited to topical therapy and 2 unreliable systemic drugs: griseofulvin and ketoconazole. Topical therapy is beneficial only for mild cases involving the very distal nail plate. The use of griseofulvin and ketoconazole is plagued by high relapse rates (70-85%), prolonged treatment regimens (10-18 mo for toenails), constant laboratory monitoring, and numerous adverse effects. The introduction of newer oral agents has revolutionized the medical treatment of OM and reduced potential adverse effects and drug interactions. As the rate of recurrence remains high, even with newer agents, the decision to treat should be made with a clear understanding of the cost and risks involved as well as the risk of recurrence..
The use of topical agents should be limited to cases involving less than half of the distal nail plate or for patients unable to tolerate systemic treatment. Agents include amorolfine (approved in other countries), ciclopirox olamine 8% nail lacquer solution, sodium pyrithione, bifonazole/urea (available outside the United States), propylene glycol-urea-lactic acid, the imidazoles, and the allylamines.
Topical treatments alone are generally unable to cure OM because of insufficient nail plate penetration. Ciclopirox solution has been reported to penetrate through all nail layers but has low efficacy when used as monotherapy. It may be useful as adjunctive therapy in combination with oral therapy or as prophylaxis to prevent recurrence in patients cured with systemic agents.
The newer generation of oral antifungal agents (itraconazole and terbinafine) has replaced older therapies in the treatment of nail fungus. They offer shorter treatment regimens, higher cure rates, and fewer adverse effects. Fluconazole (not approved by the Food and Drug Administration [FDA] for treatment of nail fungus) offers an alternative to itraconazole and terbinafine. Derivatives of fluconazole may also be available soon. The efficacy of the newer antifungal agents lies in their ability to penetrate the nail plate within days of starting therapy. Recent evidence shows better efficacy with terbinafine than other oral agents.
To decrease the adverse effects and duration of oral therapy, topical and surgical treatments may be combined with oral antifungal management.
Surgical approaches to nail fungus treatment include surgical nail avulsion and matrixectomy by chemical or mechanical means. Chemical removal by using a 40-50% urea compound should be reserved for patients with very thick nails or for those who may not tolerate mechanical avulsion.
Removal of the nail plate should be considered an adjunctive treatment in patients undergoing oral therapy.
A combination of oral, topical, and surgical therapy can increase efficacy and reduce cost.
Activity: Activity does not need to be limited during treatment, but patients should be educated about avoiding direct contact with high-risk areas in public places.
Gregory Mburu is a medical professional and a marketer part time. He post info about nail fungus on his blog at http://nail-fungus-cure.blogspot.com
10 Benefits of an Electronic Medical Record
Electronic Medical Record
UltraCET: The Dynamic Duo Of Prescription Pain Control Medications
Remember the last time you stubbed your toe? OUCH! It's painful. But a stubbed toe usually doesn't send us running to the medicine cabinet, since we know that the pain will pass within a few minutes.
Increasing Patient Care and Reducing Liability in Seven Simple Steps
When an unconscious patient arrives in the ED, every hospital agrees that timely next of kin notification is vital. Not only is it important to have a family member present to comfort the patient, but to make informed decisions for his care and provide the medical history that can make the difference between life and death. From a liability standpoint, as we know all too well, having a family member making medical decisions, often means that if complications do arise, the family will be much less likely to sue, than if they hadn't been in attendance.
Bee Propolis: Synergisitc Health Care for the 21st Centruy
For well over a century modern science has progressed at a startling rate. With this increase in knowledge has come medicinal and healthcare benefits that have seen ages peak and diseases eradicated. These medical advances were based around the paradigm of the "magic bullet", isolating the active ingredient and using it to alter the chemistry of a single molecule/protein to elicit a change of state in the patient. Success however has turned to obsession as cracks appear in the armoury of disease fighting drugs at our disposal. MRSA is rifling through our hospitals as antibiotics become ineffective and severe side effects of modern drugs are becoming common place now years after their introduction. A direct consequence of a one dimensional strategy, it is maybe the time to acknowledge the synergistic health benefits of natural medicine. Propolis is a unique natural medicine because of its breadth of action. It has antibacterial, antiviral, antifungal, anti-inflammatory, anti-cancer and immunomodulatory effects, it could help treat asthma, allergies, arthritis and joint disorders, eczema and dermatitis, ME, viral infections including HIV and even cancer. This medicine could help treat an illness or keep you fit and healthy. Propolis: Defender of the City Propolis is a mainly resinous substance that bees collect from trees and plants. Being made up of waxes, resins, fatty acids and even amino acids. Aristotle reputedly coined the name Propolis meaning "defender of the city". This is exactly what Propolis is for the hive, it acts as a bee population's external immune system keeping the hive sterile and free of microbial invaders Evidence Based Medicine In the following paragraphs I will describe to you the pharmacological properties of Propolis. Before I do so I must explain where this evidence comes from. All the properties and actions of Propolis have been witnessed and detailed in scientific studies which have subsequently been published in journals. The bulk of these scientific studies have been performed in vitro (i.e. in a test tube) or in vivo (i.e. in a host animal for example rats), a much smaller proportion of these studies are clinical trials tested on humans. The abstracts of these papers can be found on the Medline and pubmed databases on the Internet. Propolis: A natural antibiotic Propolis is probably best known for its antibiotic properties. Even as early as 1960 French1 research demonstrated the bacteriostatic action on Bacillus subtilis, Proteus vulgaris and Bacillus alvei. The results have been replicated many times and Propolis has even been shown to be effective to MRSA2, the same antibiotic resistant bacteria that has infected up to 70% of our hospitals. A 1997 study by Calder et al. at the University of Oxford concurred with these results and found that the cinnaminic acids and flavanoids present in Propolis in particular show bacteriocidal action. This action believed to be as a consequence of Propolis uncoupling the bacterial energy respiratory chain. Interestingly this action may be involved in a synergistic action with antibiotics when used together, boosting the effectiveness of the drugs. Anti-Viral and immuno-stimulatory Viruses present a unique dilemma in the quest for good health, they are not affected by antibiotics and mutate so frequently that vaccines are hard to produce. They also cause illness by hijacking cells and using the cells machinery to replicate. Modern drugs aim to slow or stop the virus from the replicating and subsequently because they are attacking host cell machinery they have certain side effects. Viruses perhaps pose the greatest threat to humans' health, we are currently in the middle of a HIV pandemic with "39.4 million" people infected world wide. With a Flu pandemic overdue and certainly on its way and predictions of world wide casualties and chaos, a solution is needed. The bioflavanoids in propolis have a unique approach to combating Viruses, instead of trying to combat them once they have infected a cell, they lock the virus in its protein coat. This means that the dangerous machinery and DNA/RNA of the virus is nullified and the infection stopped. Propolis has been shown to be more effective than the pharmaceutical anti-viral acyclovir in treating genital Herpes in a clinical trial conducted in the Ukraine4 and there is growing evidence that Propolis could help treat people with HIV5. Propolis also works hard as an immunomodulator which is of interest for all of us. It does this by altering the way cytokine production and release is managed. Cytokines are the chemical messengers that allow immune system cells to communicate. By altering the cytokine system, it primes the immune system to be ready to react to antigens quickly and effectively. As well as this, bioflavanoids within Propolis stimulate the production of interferon which can help people recover from ME, stimulating their immune system. This alteration of the cytokine and interferon systems means that your body is ready to fight off infection and keep you healthy, making a case for using propolis as a supplement for good health, like vitamins. Prevention is better than the cure. Anti-inflammatory and anti-allergen A survey of Propolis consumers showed that arthritis was the health problem that Propolis was used to treat the most. This is because of the potent anti-inflammatory properties of the propolis constituents in particular CAPE (Caffeic acid Phenyl ester), CAPE has been shown to suppress T cell activation. A paper by Marquez et al in 20046 evaluated this to mean that since T-cells play a key role in the onset of several inflammatory diseases, CAPE is important because the this phenolic compound is a potent inhibitor of early and late events in T-cell receptor-mediated T-cell activation. Results like this have led other researchers to propose that CAPE is a worthwhile agent for reducing the severity of conditions associated with inflammation. Many of the experiments performed on CAPE were done so in vitro, however the anti-inflammatory properties of Propolis have been documented in rats when treating rat adjuvant arthritis. A paper by Park et al in 19997 concluding that the ethanolic extract of propolis had profound anti-inflammatory effects on both chronic and acute arthritic inflammations. These anti-inflammation properties extend to other illness and disorders such as asthma and allergies reducing both smooth muscle airway contraction8 and allergic responses. Any disorder or illness related to inflammation could be helped by Propolis. Anti-tumour/cancer Propolis and CAPE have been shown to reduce the size of tumours and to selectively destroy and to curb the proliferation of malignant cells of many different types of cancer. As recently as June 10th 2005 Cancer researchers have been given a grant of a million dollars to investigate the therapeutic value of Propolis for cancer. Costas Koumenis the lead investigator for the study was quoted as saying, "a very interesting property of these compounds is that they have been shown to cause cell death in tumor cells but not in normal cells." This study along with other current studies promises to propel Propolis into the limelight in the field of cancer treatment. Current Propolis Research in the UK BVR (BeeVital Research) recently won a major government Research and Development Award, part of a £250,000 research programme looking at the chemical, biological and clinical properties of propolis. These studies will focus on the: 1. Documenting the regional variances in chemical and biological properties, by HPLS, GC-MS and NMR. (Taking place at Univeristy of Strathclyde) 2. Futher investigating the role of Propolis in the Hive (University of Gloucester) 3. Dental trials ? looking at effectiveness of Propolis for Mouth Ulcers, Pericorinitis, Gingivitis and Sensitive Teeth. (Manchester University Dental school) 4. HIV/AIDS trials ? looking at the effectiveness of Propolis with anti-virals in Zambia and Tanzania 5. The effects of standardised propolis on mood, stress, fatigue and cognition at the Human Cognitive Neuroscience Unit at University of Newcastle. 6. To evaluate the use of local and non ? local propolis for wound healing and the treatment of skin and other dermatological problems. ( The Regional Teaching Hospital for University of Dar es Salaam)
Medical Testing: Health By The Numbers Doesnt Work
Perhaps one of the most insidious dangers in modern technology is medical testing. Although it would be nice to be able to visit our doctor and get all hooked up with electrodes, inflatable cuffs, probes, needles and catheters and have a read-out telling us exactly how we are working and where there is a problem, that is a myth, not the reality.
At Last! Good News For Gout Sufferers!
Gout, an arthritis affliction with its roots in antiquity, has not always been easy to treat. The traditional medicines employed for gout have been non-steroidal anti-inflammatory drugs (NSAIDS), colchicines, probenicid (Benemid), and allopurinol (Zyloprim).
Bextra and Vioxx Withdrawal Spawn Advertising Pause from Bristol Myers
Pharmaceutical giant Bristol Myers Squibb has announced that they will suspend direct-to-consumer advertising for their prescription drug products for a year. This comes in the wake of the well-publicized withdrawals of Merck's Vioxx and Pfizer's Bextra, two non-steroidal anti-inflammatory drugs (NSAIDs) that were voluntarily withdrawn from the market recently. Studies showed that they increase the likelihood of strokes and heart attacks among patients that take them for prolonged periods of time. This represents an unusual move for a pharmaceutical company, as they tend to spend a large portion of their annual advertising budget on direct-to-consumer advertising.
Infants and Acid Reflux
Infant acid reflux is quite common. People of all ages, especially infants because they consume only liquids or soft foods, suffer from mild heartburn or acidic regurgitation on occasion. As in adult cases, infants experience acid reflux when the lower esophageal sphincter (LES) is relaxed. The LES acts as a valve between the esophagus and the stomach. It opens up to allow food into the stomach and then closes in order to protect the esophagus and other organs from acidic reflux. Unfortunately, it is difficult to determine if an infant has developed a chronic form of heartburn called gastroesophageal reflux disease or GERD.
Bextra and Vioxx -- Tips for Arthritis Relief Without Them
The recent withdrawal of Vioxx and Bextra from the marketplace, due to concerns over unwanted side effects, has many arthritis sufferers concerned. These drugs, which belong to a powerful class of non-steroidal anti-inflammatory drugs known as COX-2 inhibitors, are quite effective at fighting the pain and inflammation of arthritis. Unfortunately, they have been linked to increased risk of strokes and heart attacks. Their manufacturers have voluntarily withdrawn them from the market.
Lunesta Pregnancy And Breastfeeding
Lunesta is a newly released sleeping pill. Marketed as a revolutionary sleep aid, Lunesta is the only medication approved by the FDA for long term treatment of insomnia symptoms. Although Lunesta is a quality medicine that has already helped many people cure their insomnia symptoms and get a better night's sleep, there is something you should know before your buy Lunesta. This information below affects you if you're currently pregnant, breastfeeding, or are planning to become pregnant.
Health Needs of Survivors of Domestic Violence
Domestic violence is not over when the victim is safe and out of harm's way. It's not over until justice has been served. Even then, it's not over. It's not over until the victim is safe, justice has been served, and the victim is well.
Irritable Bowel Syndrome - Cybill Shepherd Reveals All
Cybill Shepherd has revealed that she suffers from irritable bowel syndrome (IBS). The star of Moonlighting and Taxi Driver says that she has struggled with her symptoms for many years, and is now hoping to raise awareness of IBS and encourage sufferers to talk more openly with their doctors.
Carpal Tunnel Syndrome - Steroid Injection for Carpal Tunnel Syndrome
What is the role of steroid injection in carpal tunnel syndrome?
Cholesterol Treatments Options: Statins
Satins are pharmacuetical drugs that work by restricting the enzyme HMG CoA reductase. This is an enzyme which regulates how fast a rate cholesterol is produced in the body. By slowing down production of this enzyme, statins are able to lower LDL cholesterol levels more efficiently than many of the other cholesterol drugs on the market.
Although you make a patient feel better, there isn't usually anything tangible to be a reminder of your service. When it comes time for the patient to pay their bills, yours is often at the bottom of the pile. You are competing with other credit grantors that supplied a tangible product, or something they really enjoy like cable or their cell phone and therefore your medical collections problem is more difficult.
Natural Vitamin E Combined with Vitamin C for Treatment of Alzheimers Disease
Checklist of Treatments for Alzheimer's Disease
The Ease of Using a Motorized Wheelchair to Improve Mobility
No person likes to feel housebound and dependent on others. While people who have been injured or suffering from a debilitating disease may not have full functionality of their motor skills, it is still possible for them to be semi-independent and mobile with motorized wheelchairs and other home medical equipment. It can't be over emphasized how critical that sense of independence can be. Quality, dependable Motorized Wheelchairs and other home medical equipment are the means of transportation that many people choose as their way to get around.
Safely Mimicking the Effects of Accutane Without the Side-effects or Costs
Since 1982 Accutane has been a reliable, if not controversial, drug for treating severe acne. Now with FDA representative David J. Graham's statement that Accutane should be taken off the market, and pharmaceutical manufacturer La Roche's defense of Accutane's safety in a Florida courtroom, access to Accutane faces mounting restrictions.
Affordable Drugs: Saving Money by Splitting Pills
One of the least appreciated cost-savers in medical treatment is the simple act of splitting pills. Suppose you're a U.S. citizen with depression who needs to take Lexapro brand of escitalopram oxalate, a commonly prescribed antidepressant, at a typical starting dose of 10 milligrams (mg) per day. Let's figure out how much your treatment will cost, both by month and by day.
Hypothermia - The Cold Facts
If you ever go to cold countries, you should undoubtedly have heard of Hypothermia. If you haven't, you should learn something about it. Your very own life may depend on knowing the information below:
|home | site map|
|Copyright © 2007 www.MyPrimaryCare.com|